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Using multiple high-throughput proteomics assays in two independent cohorts of konzo-affected children compared to unrelated individuals (Discovery) or their unaffected sibling (Validation) respectively, we demonstrate that levels of the critical plasma-based antioxidant enzyme Glutathione Peroxidase 3 (GPx3) are significantly reduced in those affected

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In support of this, the in vivo administration of GABA A receptor agonists (phenobarbital) reduced NSC proliferation and increased differentiation leading to enhanced numbers of newly generated neurons [123]